This article details the preparation of the silver used for the treatment of infected wounds: silver nitrate, silver sulfadiazine, sulfathiazole silver nanoparticle silver. The mechanisms of effective antibacterial, antiviral, antifungal and anti-inflammatory actions, positive and negative effects on wound processes, information on cytotoxicity and inhibitions of migration and proliferation of fibroblast in the wound are presented. Gathered information about challenges of antibacterial rezistentnosti to silver. A specific practical recommendation for the use of a silver-containing drug in the treatment of wounds and wound infections, taking into account the phase of wound processes, is presented. Critical reviews are given of the combination of different sulfanilamide with silver in the creation of a local form for the treatment of wounds and wound infections.
wound, wound process, wound infection, silver
1. Blaton L. A. Modern principles of General antibacterial therapy wound infection // the Chosen course of lectures on purulent surgery / edited by V. D. Fedorov and A. M. Svetukhina. M.: Miklos. 2005. P. 328-352 [Blatun L. A. Sovremennye osnovy obshhej antibakterial’noj terapii ranevoj infekcii // Izbrannyj kurs lekcij po hirurgii gnojnoj / pod red. V. D. Fedorova i Svetuhina A. M. M.: Miklosh. 2005. S. 328-352 (in Russian)].
2. Shlyapnikov S. Surgical soft tissue infections-an old problem in the new world. Infections in surgery. RASHI. Vol.1. 2003. No. 1. S. 14-21 [S. A. Shljapnikov Hirurgicheskie infekcii mjagkih tkanej - staraja problema v novom svete // Infekcii v hirurgii. RASHI. T. 1. 2003. No. 1. S. 14-21 (in Russian)].
3. Wounds and wound infection / edited by M. I. Kuzin, B. M. and Kostuchenko. M., 1981, Bibliogr. [Rany i ranevaja infekcija, pod red. M. I. B. M. Kuzina i Kostjuchenka. M., 1981, bibliogr. (in Russian)].
4. Azovskov O. V., Ivanchik N. In. Dekhnich A.V., Kretchikova O. I., Kozlov R. S. Dynamics of antibiotic resistance respiratory strains of Streptococcus pyogenes in Russia for the period 1999-2009 // Clinical Microbiology and antimicrobial chemotherapy. 2012. Vol. 14 (№4). P. 309-321 [Azovskova O. V., N. V. Ivanchik, A. V. Dehnich, Krechikova O. I., Kozlov R. S. Dinamika antibiotikorezistentnosti respiratornyh shtammov Streptococcus pyogenes v Rossii za period 1999-2009 gg. // Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2012. T. 14 (no. 4). S. 309-321 (in Russian)].
5. Kozlov R. S., Golub A. V. Strategy of antimicrobial use as an attempt of antibiotics Renaissance / / Clinical Microbiology and antimicrobial chemotherapy. 2011. Vol. 13 (№4). P. 322-334 [Kozlov R. S., Golub V. A. Strategija ispol’zovanija antimikrobnyh preparatov kak popytka renessansa antibiotikov // Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2011. (No. 13). S. 322-334 (in Russian)].
